|
KMID : 0363220160540070552
|
|
Korean Journal of Dermatology
2016 Volume.54 No. 7 p.552 ~ p.556
|
|
|
A Case of Woringer-Kolopp Disease of the Hand
|
|
Ryu Ha-Ryeong
Kim Jeong-Soo
Yun Chul-Hyun
Kim Ji-Hoon
Roh Joo-Young
Lee Jong-Rok
Kim Hyun-Chul
Baek Jin-Ok
|
|
|
Abstract
|
|
|
|
Woringer-Kolopp disease, also known as localized pagetoid reticulosis, is a rare variant of mycosis fungoides that presents as a solitary localized hyperkeratotic patch or plaque on the extremities and follows a benign course. Effective treatments for Woringer-Kolopp disease include skin-directed therapies such as topical nitrogen mustard, high-potency topical steroids, and phototherapy. Surgical excision has been pursued in cases of small, localized lesions. A 39-year-old man presented with a 3-month history of an asymptomatic plaque on his hand. Physical examination showed a 10-mm-diameter solitary round erythematous hyperkeratotic plaque with a slightly raised edge on the dorsum of his left hand. A skin biopsy revealed that numerous atypical lymphocytes had infiltrated the upper dermis and expanded into the epidermis with a pagetoid pattern. These atypical pagetoid cells were strongly positive for CD3, CD8, and T-cell intracellular antigen-1; focally positive for CD4; and negative for CD20, CD30, and CD56. A subsequent general examination revealed no evidence of systemic involvement and the lesion was treated with surgical excision. Here we report a rare case of Woringer-Kolopp disease.
|
|
|
KEYWORD
|
|
|
Woringer-Kolopp disease, Pagetoid reticulosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|